Telomerase, Immortality, and Cancer
نویسندگان
چکیده
منابع مشابه
Telomerase-Independent Paths to Immortality in Predictable Cancer Subtypes
The vast majority of cancers commandeer the activity of telomerase - the remarkable enzyme responsible for prolonging cellular lifespan by maintaining the length of telomeres at the ends of chromosomes. Telomerase is only normally active in embryonic and highly proliferative somatic cells. Thus, targeting telomerase is an attractive anti-cancer therapeutic rationale currently under investigatio...
متن کاملImmortality.
“Is death necessary?“, asked biologist G. R. Taylor and stated that in 1968 in the USA alone more than a thousand teams of scientists were working on the issue of growing old and the problem of death. Some people are frozen at their death. They want to be revived as soon as a cure for their disease or the aging process has been found. Most of humanity seems to have the desire to live forever. M...
متن کاملTelomerase and cancer.
Telomerase, a eukaryotic ribonucleoprotein (RNP) complex, contains both an essential RNA and a protein reverse transcriptase subunit. By reverse transcription, the telomerase RNP maintains telomere length stability in almost all cancer cells. Over the past few years there has been significant progress in identifying the components of the telomerase holoenzyme complex and the proteins that assoc...
متن کاملTelomerase and Cancer
Telomerase is commonly expressed in human cancer cells. Increased telomerase expression produces vulnerability of cancer cells, distinguishing them from normal cells in the body, although normal cells do also have some active telomerase. Recent studies also suggest that telomerase is implicated in tumor progression in unexpected ways. These observations lead us to investigate the most efficient...
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Hypoxia and acidosis are hallmarks of tumors as well as critical determinants of response to cancer treatments. The development of tumor hypoxia has been shown to be a critical step in tumorigenesis and cancer cell metastasis. Low tumor pO2 has been correlated with poor patient survival and metastasis in several types of cancer. Specifically, cyclical hypoxia was found to be associated with sig...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 2000
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-200002000-00002